Specific sequences of the Sm and Sm-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product (SMN)
WJ Friesen, G Dreyfuss - Journal of Biological Chemistry, 2000 - ASBMB
The spinal muscular atrophy disease gene product (SMN) is crucial for small nuclear
ribonuclear protein (snRNP) biogenesis in the cytoplasm and plays a role in pre-mRNA
splicing in the nucleus. SMN oligomers interact avidly with the snRNP core proteins SmB,-
D1, and-D3. We have delineated the specific sequences in the Sm proteins that mediate
their interaction with SMN. We show that unique carboxyl-terminal arginine-and glycine-rich
domains comprising the last 29 amino acids of SmD1 and the last 32 amino acids of SmD3 …
ribonuclear protein (snRNP) biogenesis in the cytoplasm and plays a role in pre-mRNA
splicing in the nucleus. SMN oligomers interact avidly with the snRNP core proteins SmB,-
D1, and-D3. We have delineated the specific sequences in the Sm proteins that mediate
their interaction with SMN. We show that unique carboxyl-terminal arginine-and glycine-rich
domains comprising the last 29 amino acids of SmD1 and the last 32 amino acids of SmD3 …
