The neural circuitry that mediates mood under normal and abnormal conditions remains
incompletely understood. Most attention in the field has focused on hippocampal and frontal
cortical regions for their role in depression and antidepressant action. While these regions
no doubt play important roles in these phenomena, there is compelling evidence that other
brain regions are also involved. Here we focus on the potential role of the nucleus
accumbens (NAc; ventral striatum) and its dopaminergic input from the ventral tegmental …