Common genetic variation near MC4R is associated with waist circumference and insulin resistance
Nature genetics, 2008•nature.com
We carried out a genome-wide association study (318,237 SNPs) for insulin resistance and
related phenotypes in 2,684 Indian Asians, with further testing in 11,955 individuals of Indian
Asian or European ancestry. We found associations of rs12970134 near MC4R with waist
circumference (P= 1.7× 10− 9) and, independently, with insulin resistance. Homozygotes for
the risk allele of rs12970134 have∼ 2 cm increased waist circumference. Common genetic
variation near MC4R is associated with risk of adiposity and insulin resistance.
related phenotypes in 2,684 Indian Asians, with further testing in 11,955 individuals of Indian
Asian or European ancestry. We found associations of rs12970134 near MC4R with waist
circumference (P= 1.7× 10− 9) and, independently, with insulin resistance. Homozygotes for
the risk allele of rs12970134 have∼ 2 cm increased waist circumference. Common genetic
variation near MC4R is associated with risk of adiposity and insulin resistance.
Abstract
We carried out a genome-wide association study (318,237 SNPs) for insulin resistance and related phenotypes in 2,684 Indian Asians, with further testing in 11,955 individuals of Indian Asian or European ancestry. We found associations of rs12970134 near MC4R with waist circumference (P = 1.7 × 10−9) and, independently, with insulin resistance. Homozygotes for the risk allele of rs12970134 have ∼2 cm increased waist circumference. Common genetic variation near MC4R is associated with risk of adiposity and insulin resistance.
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