[HTML][HTML] Disruption of CXC motif chemokine ligand-14 in mice ameliorates obesity-induced insulin resistance
N Nara, Y Nakayama, S Okamoto, H Tamura… - Journal of Biological …, 2007 - ASBMB
In obese individuals, white adipose tissue (WAT) is infiltrated by large numbers of
macrophages, resulting in enhanced inflammatory responses that contribute to insulin
resistance. Here we show that expression of the CXC motif chemokine ligand-14 (CXCL14),
which targets tissue macrophages, is elevated in WAT of obese mice fed a high fat diet
(HFD) compared with lean mice fed a regular diet. We found that HFD-fed CXCL14-deficient
mice have impaired WAT macrophage mobilization and improved insulin responsiveness …
macrophages, resulting in enhanced inflammatory responses that contribute to insulin
resistance. Here we show that expression of the CXC motif chemokine ligand-14 (CXCL14),
which targets tissue macrophages, is elevated in WAT of obese mice fed a high fat diet
(HFD) compared with lean mice fed a regular diet. We found that HFD-fed CXCL14-deficient
mice have impaired WAT macrophage mobilization and improved insulin responsiveness …