There is a wide range of animal models of tuberculosis; which is fortunate, given that there is
a wide range of complex biological phenomena to model. Nonetheless, the inadequacy of
animal models is a chronic grievance amongst researchers, often expressed in the
conclusion that the mouse is not a good model of human tuberculosis. There clearly are
major differences between experimental infection of mice and natural infection of humans,
but this overarching dogma is inconducive to fruitful research.