Contribution of invariant residues to the function of Rgg family transcription regulators
JA Loughman, MG Caparon - Journal of bacteriology, 2007 - Am Soc Microbiol
JA Loughman, MG Caparon
Journal of bacteriology, 2007•Am Soc MicrobiolThe Rgg family of transcription regulators is widely distributed among gram-positive
bacteria, yet how these proteins control transcription is poorly understood. Using
Streptococcus pyogenes RopB as a model, we demonstrated that residues invariant among
Rgg-like regulators are critical for function and obtained evidence for a mechanism involving
protein complex formation.
bacteria, yet how these proteins control transcription is poorly understood. Using
Streptococcus pyogenes RopB as a model, we demonstrated that residues invariant among
Rgg-like regulators are critical for function and obtained evidence for a mechanism involving
protein complex formation.
Abstract
The Rgg family of transcription regulators is widely distributed among gram-positive bacteria, yet how these proteins control transcription is poorly understood. Using Streptococcus pyogenes RopB as a model, we demonstrated that residues invariant among Rgg-like regulators are critical for function and obtained evidence for a mechanism involving protein complex formation.
American Society for Microbiology