Regulation of hepatocyte thyroxine 5′-deiodinase by T3 and nuclear receptor coactivators as a model of the sick euthyroid syndrome
J Yu, RJ Koenig - Journal of Biological Chemistry, 2000 - ASBMB
The syndrome of nonthyroidal illness, also known as the sick euthyroid syndrome, is
characterized by a low plasma T3 and an" inappropriately normal" plasma thyrotropin in the
absence of intrinsic disease of the hypothalamic-pituitary-thyroid axis. The syndrome is due
in part to decreased activity of type I iodothyronine 5′-deiodinase (5′ DI), the hepatic
enzyme that converts thyroxine to T3 and that is induced at the transcriptional level by T3.
The hypothesis tested is that cytokines decrease T3 induction of 5′ DI, resulting in …
characterized by a low plasma T3 and an" inappropriately normal" plasma thyrotropin in the
absence of intrinsic disease of the hypothalamic-pituitary-thyroid axis. The syndrome is due
in part to decreased activity of type I iodothyronine 5′-deiodinase (5′ DI), the hepatic
enzyme that converts thyroxine to T3 and that is induced at the transcriptional level by T3.
The hypothesis tested is that cytokines decrease T3 induction of 5′ DI, resulting in …
