CD98hc (SLC3A2) interaction with β1 integrins is required for transformation
NC Henderson, EA Collis, AC Mackinnon… - Journal of Biological …, 2004 - ASBMB
CD98hc (SLC3A2) constitutively and specifically associates with β 1 integrins and is highly
expressed on the surface of human tumor cells irrespective of the tissue of origin. We have
found here that expression of CD98hc promotes both anchorage-and serum-independent
growth. This oncogenic activity is dependent on β 1 integrin-mediated phosphoinositol 3-
hydroxykinase stimulation and the level of surface expression of CD98hc. Using chimeras of
CD98hc and the type II membrane protein CD69, we show that the transmembrane domain …
expressed on the surface of human tumor cells irrespective of the tissue of origin. We have
found here that expression of CD98hc promotes both anchorage-and serum-independent
growth. This oncogenic activity is dependent on β 1 integrin-mediated phosphoinositol 3-
hydroxykinase stimulation and the level of surface expression of CD98hc. Using chimeras of
CD98hc and the type II membrane protein CD69, we show that the transmembrane domain …
