[HTML][HTML] Sterol synthesis is up-regulated in cholesterol-loaded pigeon macrophages during induction of cholesterol efflux
BK Nordskog, JW Reagan, RWS Clair - Journal of lipid research, 1999 - ASBMB
The extent to which cholesterol synthesis is modulated in macrophage foam cells by
changes in cholesterol influx and efflux was determined using thioglycollate-elicited
peritoneal macrophages from normal and cholesterol-fed White Carneau (WC) and Show
Racer (SR) pigeons. In peritoneal macrophages from normocholesterolemic pigeons, sterol
synthesis from [14 C]-acetate was down-regulated by more than 90% following incubation in
vitro with β-VLDL. Sterol synthesis was increased when the cellular free cholesterol …
changes in cholesterol influx and efflux was determined using thioglycollate-elicited
peritoneal macrophages from normal and cholesterol-fed White Carneau (WC) and Show
Racer (SR) pigeons. In peritoneal macrophages from normocholesterolemic pigeons, sterol
synthesis from [14 C]-acetate was down-regulated by more than 90% following incubation in
vitro with β-VLDL. Sterol synthesis was increased when the cellular free cholesterol …
