G1 cyclin/cyclin-dependent kinase-coordinated phosphorylation of endogenous pocket proteins differentially regulates their interactions with E2F4 and E2F1 and …
J Calbó, M Parreno, E Sotillo, T Yong, A Mazo… - Journal of Biological …, 2002 - ASBMB
Mitogenic stimulation leads to activation of G 1 cyclin-dependent kinases (CDKs), which
phosphorylate pocket proteins and trigger progression through the G 0/G 1 and G 1/S
transitions of the cell cycle. However, the individual role of G 1 cyclin-CDK complexes in the
coordinated regulation of pocket proteins and their interaction with E2F family members is
not fully understood. Here we report that individually or in concert cyclin D1-CDK and cyclin
E-CDK complexes induce distinct and coordinated phosphorylation of endogenous pocket …
phosphorylate pocket proteins and trigger progression through the G 0/G 1 and G 1/S
transitions of the cell cycle. However, the individual role of G 1 cyclin-CDK complexes in the
coordinated regulation of pocket proteins and their interaction with E2F family members is
not fully understood. Here we report that individually or in concert cyclin D1-CDK and cyclin
E-CDK complexes induce distinct and coordinated phosphorylation of endogenous pocket …