Multiple autoantigen mimotopes of infectious agents induce autoimmune arthritis and uveitis in lewis rats
G Wildner, M Diedrichs-Moehring - Clinical and Vaccine …, 2005 - Am Soc Microbiol
G Wildner, M Diedrichs-Moehring
Clinical and Vaccine Immunology, 2005•Am Soc MicrobiolWe found multimolecular antigenic mimicry of arthritogenic autoantigens and peptides from
several other “self” or foreign antigens sharing amino acid sequence homologies. Many of
these new mimotopes induced arthritis and/or uveitis upon immunization in Lewis rats,
indicating a role for multiple antigens in the initiation of a certain autoimmune disease.
several other “self” or foreign antigens sharing amino acid sequence homologies. Many of
these new mimotopes induced arthritis and/or uveitis upon immunization in Lewis rats,
indicating a role for multiple antigens in the initiation of a certain autoimmune disease.
Abstract
We found multimolecular antigenic mimicry of arthritogenic autoantigens and peptides from several other “self” or foreign antigens sharing amino acid sequence homologies. Many of these new mimotopes induced arthritis and/or uveitis upon immunization in Lewis rats, indicating a role for multiple antigens in the initiation of a certain autoimmune disease.
American Society for Microbiology