• Uveitis was induced in rhesus monkeys immunized with purified retinal Santigen. Focal
retinal and subretinal infiltration, in addition to periphlebitic changes, were observed
histologically. Immunized monkeys had similar cellmediated in vitro immune responses to
the S-antigen as do humans with posterior uveitis. Circulating immune complexes at the time
of disease could not be detected. This primate model supports the notion that the S-antigen
may play a role in human uveitis.