Rimonabant ameliorates insulin resistance via both adiponectin-dependent and adiponectin-independent pathways
T Watanabe, N Kubota, M Ohsugi, T Kubota… - Journal of biological …, 2009 - ASBMB
Rimonabant has been shown to not only decrease the food intake and body weight but also
to increase serum adiponectin levels. This increase of the serum adiponectin levels has
been hypothesized to be related to the rimonabant-induced amelioration of insulin
resistance linked to obesity, although experimental evidence to support this hypothesis is
lacking. To test this hypothesis experimentally, we generated adiponectin knock-out (adipo (-
/-)) ob/ob mice. After 21 days of 30 mg/kg rimonabant, the body weight and food intake …
to increase serum adiponectin levels. This increase of the serum adiponectin levels has
been hypothesized to be related to the rimonabant-induced amelioration of insulin
resistance linked to obesity, although experimental evidence to support this hypothesis is
lacking. To test this hypothesis experimentally, we generated adiponectin knock-out (adipo (-
/-)) ob/ob mice. After 21 days of 30 mg/kg rimonabant, the body weight and food intake …