[HTML][HTML] Positive regulation of the BRCA1 promoter
S Thakur, CM Croce - Journal of Biological Chemistry, 1999 - ASBMB
Inherited mutations in the BRCA1gene, presumably leading to loss of function, confer
susceptibility to breast and ovarian neoplasms and are thought to be responsible for
approximately 2.5–5% of all breast cancers. It has been suggested that alternative
mechanisms, such as disruption of transcription, may also be involved in the suppression of
BRCA1 gene expression/function in breast cancers. Therefore, we initiated studies on the
BRCA1 transcriptional promoter. Utilizing systematic promoter deletions and transient …
susceptibility to breast and ovarian neoplasms and are thought to be responsible for
approximately 2.5–5% of all breast cancers. It has been suggested that alternative
mechanisms, such as disruption of transcription, may also be involved in the suppression of
BRCA1 gene expression/function in breast cancers. Therefore, we initiated studies on the
BRCA1 transcriptional promoter. Utilizing systematic promoter deletions and transient …