Different expression of apoptotic proteins between HBV-infected and non-HBV-infected hepatocellular carcinoma.
CS Chang, SM Huang, HH Lin, CC Wu… - Hepato …, 2007 - europepmc.org
CS Chang, SM Huang, HH Lin, CC Wu, CJ Wang
Hepato-gastroenterology, 2007•europepmc.orgResults The expression of PI-3K, Cdc-42, caspase 3, NF-kappaB, Bcl-2, Bad-p and Bax
were higher in cancer tissues with HBV infection than para-cancerous liver tissues and
cancer tissues without HBV infection. The expressions of PI-3K were significantly higher in
cancer tissues with the HBV infection when compared to para-cancerous liver tissues.
Furthermore, PI-3K concentrations were significantly higher in stages III and IV HCC than in
stages I and II HCC (1.48+/-0.25 vs. 1.07+/-0.25, p< 0.01). On the contrary, the expressions …
were higher in cancer tissues with HBV infection than para-cancerous liver tissues and
cancer tissues without HBV infection. The expressions of PI-3K were significantly higher in
cancer tissues with the HBV infection when compared to para-cancerous liver tissues.
Furthermore, PI-3K concentrations were significantly higher in stages III and IV HCC than in
stages I and II HCC (1.48+/-0.25 vs. 1.07+/-0.25, p< 0.01). On the contrary, the expressions …
Results
The expression of PI-3K, Cdc-42, caspase 3, NF-kappaB, Bcl-2, Bad-p and Bax were higher in cancer tissues with HBV infection than para-cancerous liver tissues and cancer tissues without HBV infection. The expressions of PI-3K were significantly higher in cancer tissues with the HBV infection when compared to para-cancerous liver tissues. Furthermore, PI-3K concentrations were significantly higher in stages III and IV HCC than in stages I and II HCC (1.48+/-0.25 vs. 1.07+/-0.25, p< 0.01). On the contrary, the expressions of Mcl-1 in cancer tissues were lower than para-cancerous liver tissue in both HCC with HBV infection and without HBV infection.
Conclusions
Our data indicate that different expressions of PI-3K, Cdc-42, Bcl-2 and Bad-p were noticed between HBV-infected and non-HBV infected HCC. Therefore, different transcriptional pathways may be involved in the developing of HCC between HBV-infected and non-HBV infected patients.
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