Snail, a transcriptional repressor of E-cadherin expression, plays a role in the process of
epithelial-mesenchymal transition. However, the molecular basis of the role of snail in
epithelial-mesenchymal transition has not been fully clarified. Here we show that the
expression of snail in epithelial Madin-Darby canine kidney (MDCK) and A431 cells
enhances both cell detachment and attachment. Snail did not confer resistance to anoikis
induced by loss of contact but instead enhanced cell attachment to extracellular matrices …