Mechanism of intestinal lipoprotein overproduction in insulin resistant humans
H Duez, M Pavlic, GF Lewis - Atherosclerosis Supplements, 2008 - Elsevier
Triglyceride-rich lipoproteins (TRLs) derived from the intestine are increased in insulin
resistant states both in the post-prandial and fasted state and are associated with increased
cardiovascular risk. Impaired clearance has long been invoked to explain this accumulation
of intestinal TRLs, but more recent studies have highlighted the fact that the production rate
of apolipoprotein (apo) B-48-containing particles is also increased in insulin resistance and
Type 2 diabetes. Recent data also indicate that the enterocyte, similar to the hepatocyte …
resistant states both in the post-prandial and fasted state and are associated with increased
cardiovascular risk. Impaired clearance has long been invoked to explain this accumulation
of intestinal TRLs, but more recent studies have highlighted the fact that the production rate
of apolipoprotein (apo) B-48-containing particles is also increased in insulin resistance and
Type 2 diabetes. Recent data also indicate that the enterocyte, similar to the hepatocyte …
