A critical role of CpG motifs in a murine peritonitis model by their binding to highly expressed toll-like receptor-9 on liver NKT cells
H Tsujimoto, S Ono, A Matsumoto, T Kawabata… - Journal of …, 2006 - Elsevier
BACKGROUNDS: Toll-like receptor (TLR)-9 plays a critical role in the recognition of the CpG
motifs, which is frequently observed in bacterial DNA. To date, there have not been any
reports regarding the role of bacterial DNA in the systemic circulation on the development of
sepsis. METHODS: We examined the expression of TLR-9 in the liver and spleen in a
murine peritonitis model (CLP mice). We also measured the cytokine response of
mononuclear cells (MNCs) from normal and CLP mice to CpG oligodeoxynucleotides (ODN) …
motifs, which is frequently observed in bacterial DNA. To date, there have not been any
reports regarding the role of bacterial DNA in the systemic circulation on the development of
sepsis. METHODS: We examined the expression of TLR-9 in the liver and spleen in a
murine peritonitis model (CLP mice). We also measured the cytokine response of
mononuclear cells (MNCs) from normal and CLP mice to CpG oligodeoxynucleotides (ODN) …
