Observations on the role of tumor necrosis factor-α in a murine model of shock due to Streptococcus pyogenes
J Wayte, AT Silva, T Krausz, J Cohen - Critical care medicine, 1993 - journals.lww.com
Objective: To examine the effect of a monoclonal antibody to tumor necrosis factor-
[alpha](TNF-[alpha]) in a murine model of shock due to Streptococcus pyogenes. Design:
Prospective, multiexperimental, randomized, controlled trial. Setting: University hospital
research laboratory. Interventions: An LD90 murine model of Grampositive shock using S.
pyogenes, associated with the presence of significant concentrations of TNF-[alpha] in the
circulation. Prophylactic administration of antibody with concomitant saline controls. A 500 …
[alpha](TNF-[alpha]) in a murine model of shock due to Streptococcus pyogenes. Design:
Prospective, multiexperimental, randomized, controlled trial. Setting: University hospital
research laboratory. Interventions: An LD90 murine model of Grampositive shock using S.
pyogenes, associated with the presence of significant concentrations of TNF-[alpha] in the
circulation. Prophylactic administration of antibody with concomitant saline controls. A 500 …
