Postmortem molecular analysis of SCN5A defects in sudden infant death syndrome
MJ Ackerman, BL Siu, WQ Sturner, DJ Tester… - Jama, 2001 - jamanetwork.com
Context Fatal arrhythmias from occult long QT syndrome may be responsible for some cases
of sudden infant death syndrome (SIDS). Because patients who have long QT syndrome
with sodium channel gene (SCN5A) defects have an increased frequency of cardiac events
during sleep, and a recent case is reported of a sporadic SCN5Amutation in an infant with
near SIDS, SCN5A has emerged as the leading candidate ion channel gene for SIDS.
Objective To determine the prevalence and functional properties of SCN5A mutations in …
of sudden infant death syndrome (SIDS). Because patients who have long QT syndrome
with sodium channel gene (SCN5A) defects have an increased frequency of cardiac events
during sleep, and a recent case is reported of a sporadic SCN5Amutation in an infant with
near SIDS, SCN5A has emerged as the leading candidate ion channel gene for SIDS.
Objective To determine the prevalence and functional properties of SCN5A mutations in …