[HTML][HTML] Constitutive endocytic cycle of the CB1 cannabinoid receptor
The CB1 cannabinoid receptor (CB1R) displays a significant level of ligand-independent (ie
constitutive) activity, either when heterologously expressed in nonneuronal cells or in
neurons where CB1Rs are endogenous. The present study investigates the consequences
of constitutive activity on the intracellular trafficking of CB1R. When transfected in HEK-293
cells, CB1R is present at the plasma membrane, but a substantial proportion (∼ 85%) of
receptors is localized in intracellular vesicles. Detailed analysis of CB1-EGFP expressed in …
constitutive) activity, either when heterologously expressed in nonneuronal cells or in
neurons where CB1Rs are endogenous. The present study investigates the consequences
of constitutive activity on the intracellular trafficking of CB1R. When transfected in HEK-293
cells, CB1R is present at the plasma membrane, but a substantial proportion (∼ 85%) of
receptors is localized in intracellular vesicles. Detailed analysis of CB1-EGFP expressed in …