[HTML][HTML] Cardiac type 2 inositol 1, 4, 5-trisphosphate receptor: interaction and modulation by calcium/calmodulin-dependent protein kinase II
DJ Bare, CS Kettlun, M Liang, DM Bers… - Journal of Biological …, 2005 - ASBMB
The type 2 inositol 1, 4, 5-trisphosphate receptor (InsP 3 R2) was identified previously as the
predominant isoform in cardiac ventricular myocytes. Here we reported the subcellular
localization of InsP 3 R2 to the cardiomyocyte nuclear envelope (NE). The other major
known endo/sarcoplasmic reticulum calcium-release channel (ryanodine receptor) was not
localized to the NE, indicating functional segregation of these channels and possibly a
unique role for InsP 3 R2 in regulating nuclear calcium dynamics. Immunoprecipitation …
predominant isoform in cardiac ventricular myocytes. Here we reported the subcellular
localization of InsP 3 R2 to the cardiomyocyte nuclear envelope (NE). The other major
known endo/sarcoplasmic reticulum calcium-release channel (ryanodine receptor) was not
localized to the NE, indicating functional segregation of these channels and possibly a
unique role for InsP 3 R2 in regulating nuclear calcium dynamics. Immunoprecipitation …