Anaphylaxis: a review of causes and mechanisms
SF Kemp, RF Lockey - Journal of allergy and clinical immunology, 2002 - Elsevier
Anaphylaxis is a life-threatening syndrome resulting from the sudden release of mast cell-
and basophil-derived mediators into the circulation. Foods and medications cause most
anaphylaxis for which a cause can be identified, but virtually any agent capable of directly or
indirectly activating mast cells or basophils can cause this syndrome. This review discusses
the pathophysiologic mechanisms of anaphylaxis, its causes, and its treatment.(J Allergy
Clin Immunol 2002; 110: 341-8.)
and basophil-derived mediators into the circulation. Foods and medications cause most
anaphylaxis for which a cause can be identified, but virtually any agent capable of directly or
indirectly activating mast cells or basophils can cause this syndrome. This review discusses
the pathophysiologic mechanisms of anaphylaxis, its causes, and its treatment.(J Allergy
Clin Immunol 2002; 110: 341-8.)