Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2
SF Kim, DA Huri, SH Snyder - Science, 2005 - science.org
SF Kim, DA Huri, SH Snyder
Science, 2005•science.orgCyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) are two major
inflammatory mediators. Here we show that iNOS specifically binds to COX-2 and S-
nitrosylates it, enhancing COX-2 catalytic activity. Selectively disrupting iNOS–COX-2
binding prevented NO-mediated activation of COX-2. This synergistic molecular interaction
between two inflammatory systems may inform the development of anti-inflammatory drugs.
inflammatory mediators. Here we show that iNOS specifically binds to COX-2 and S-
nitrosylates it, enhancing COX-2 catalytic activity. Selectively disrupting iNOS–COX-2
binding prevented NO-mediated activation of COX-2. This synergistic molecular interaction
between two inflammatory systems may inform the development of anti-inflammatory drugs.
Cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) are two major inflammatory mediators. Here we show that iNOS specifically binds to COX-2 and S-nitrosylates it, enhancing COX-2 catalytic activity. Selectively disrupting iNOS–COX-2 binding prevented NO-mediated activation of COX-2. This synergistic molecular interaction between two inflammatory systems may inform the development of anti-inflammatory drugs.
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