Protein kinase Cι promotes nicotine-induced migration and invasion of cancer cells via phosphorylation of μ-and m-calpains
L Xu, X Deng - Journal of Biological Chemistry, 2006 - ASBMB
Nicotine is a major component in cigarette smoke that activates the growth-promoting
pathways to facilitate the development of lung cancer. However, it is not clear whether
nicotine affects cell motility to facilitate tumor metastasis. Here we discovered that nicotine
potently induces phosphorylation of both μ-and m-calpains via activation of protein kinase Cι
(PKCι), which is associated with accelerated migration and invasion of human lung cancer
cells. Purified PKCι directly phosphorylates μ-and m-calpains in vitro. Overexpression of …
pathways to facilitate the development of lung cancer. However, it is not clear whether
nicotine affects cell motility to facilitate tumor metastasis. Here we discovered that nicotine
potently induces phosphorylation of both μ-and m-calpains via activation of protein kinase Cι
(PKCι), which is associated with accelerated migration and invasion of human lung cancer
cells. Purified PKCι directly phosphorylates μ-and m-calpains in vitro. Overexpression of …
