[HTML][HTML] Functional reconstitution of human FcRn in Madin-Darby canine kidney cells requires co-expressed human β2-microglobulin
The major histocompatibility complex class I-related neonatal Fc receptor, FcRn, assembles
as a heterodimer consisting of a heavy chain and β 2-microglobulin (β 2 m), which is
essential for FcRn function. We observed that, in Madin-Darby canine kidney (MDCK) cells,
the function of human FcRn in mediating the bidirectional transport of IgG was significantly
increased upon co-expression of the human isoform of β 2 m. In MDCK cells, the presence
of human β 2 m endowed upon human FcRn an enhanced ability to exit the endoplasmic …
as a heterodimer consisting of a heavy chain and β 2-microglobulin (β 2 m), which is
essential for FcRn function. We observed that, in Madin-Darby canine kidney (MDCK) cells,
the function of human FcRn in mediating the bidirectional transport of IgG was significantly
increased upon co-expression of the human isoform of β 2 m. In MDCK cells, the presence
of human β 2 m endowed upon human FcRn an enhanced ability to exit the endoplasmic …