Several characteristics confer on B cells the ability to present antigen efficiently:(1) they can
find T cells in secondary lymphoid organs shortly after antigen entrance,(2) BCR-mediated
endocytosis allows them to concentrate small amounts of specific antigen, and (3) BCR
signaling and HLA-DO expression direct their antigen processing machinery to favor
presentation of antigens internalized through the BCR. When presenting antigen in a resting
state, B cells can induce T cell tolerance. On the other hand, activation by antigen and T cell …