Complete amino acid sequence of canine cardiac calsequestrin deduced by cDNA cloning.
BT Scott, HK Simmerman, JH Collins… - Journal of Biological …, 1988 - ASBMB
cDNA cloning was used to deduce the complete amino acid sequence of canine cardiac
calsequestrin, the principal Ca2+-binding protein of cardiac junctional sarcoplasmic
reticulum. Cardiac calsequestrin contains 391 amino acid residues plus a 19-residue amino-
terminal signal sequence. The molecular weight of the mature protein, excluding
carbohydrate, is 45,269. Cardiac calsequestrin is highly acidic, and a striking feature is the
enrichment of acidic residues (60%) within the 63 carboxyl-terminal residues. No part of the …
calsequestrin, the principal Ca2+-binding protein of cardiac junctional sarcoplasmic
reticulum. Cardiac calsequestrin contains 391 amino acid residues plus a 19-residue amino-
terminal signal sequence. The molecular weight of the mature protein, excluding
carbohydrate, is 45,269. Cardiac calsequestrin is highly acidic, and a striking feature is the
enrichment of acidic residues (60%) within the 63 carboxyl-terminal residues. No part of the …
