Mechanisms contributing to muscle-wasting in acute uremia: activation of amino acid catabolism.
SR Price, D Reaich, AC Marinovic… - Journal of the …, 1998 - journals.lww.com
Acute uremia (ARF) causes metabolic defects in glucose and protein metabolism that
contribute to muscle wasting. To examine whether there are also defects in the metabolism
of essential amino acids in ARF, we measured the activity of the rate-limiting enzyme for
branched-chain amino acid catabolism, branched-chain ketoacid dehydrogenase (BCKAD),
in rat muscles. Because chronic acidosis activates muscle BCKAD, we also evaluated the
influence of acidosis by studying ARF rats given either NaCl (ARF-NaCl) or NaHCO3 (ARF …
contribute to muscle wasting. To examine whether there are also defects in the metabolism
of essential amino acids in ARF, we measured the activity of the rate-limiting enzyme for
branched-chain amino acid catabolism, branched-chain ketoacid dehydrogenase (BCKAD),
in rat muscles. Because chronic acidosis activates muscle BCKAD, we also evaluated the
influence of acidosis by studying ARF rats given either NaCl (ARF-NaCl) or NaHCO3 (ARF …