MHC Class II tetramers and the pursuit of antigen-specific T cells: define, deviate, delete
R Mallone, GT Nepom - Clinical Immunology, 2004 - Elsevier
Selective expansion and activation of a very small number of antigen-specific CD4+ T cells
is a remarkable and essential property of the adaptive immune response. Antigen-specific T
cells were until recently identified only indirectly by functional assays, such as antigen-
induced cytokine secretion and proliferation. The advent of MHC Class II tetramers has
added a pivotal tool to our research armamentarium, allowing the definition of allo-and
autoimmune responses in deeper detail. Rare antigen-specific CD4+ cells can now be …
is a remarkable and essential property of the adaptive immune response. Antigen-specific T
cells were until recently identified only indirectly by functional assays, such as antigen-
induced cytokine secretion and proliferation. The advent of MHC Class II tetramers has
added a pivotal tool to our research armamentarium, allowing the definition of allo-and
autoimmune responses in deeper detail. Rare antigen-specific CD4+ cells can now be …