[HTML][HTML] Disruption of nuclear vitamin D receptor gene causes enhanced thrombogenicity in mice
K Aihara, H Azuma, M Akaike, Y Ikeda… - Journal of Biological …, 2004 - ASBMB
Vitamin D metabolites influence the expression of various genes involved in calcium
homeostasis, cell differentiation, and regulation of the immune system. Expression of these
genes is mediated by the activation of the nuclear vitamin D receptor (VDR). Previous
studies have shown that a hormonally active form of vitamin D, 1α, 25-dihydroxyvitamin D3,
exerts anticoagulant effects in cultured monocytic cells. To clarify whether activation of VDR
plays any antithrombotic actions in vivo, hemostatic/thrombogenic systems were examined …
homeostasis, cell differentiation, and regulation of the immune system. Expression of these
genes is mediated by the activation of the nuclear vitamin D receptor (VDR). Previous
studies have shown that a hormonally active form of vitamin D, 1α, 25-dihydroxyvitamin D3,
exerts anticoagulant effects in cultured monocytic cells. To clarify whether activation of VDR
plays any antithrombotic actions in vivo, hemostatic/thrombogenic systems were examined …
