Proteolytic activation of hepatocyte growth factor in response to tissue injury.
K Miyazawa, T Shimomura, D Naka… - Journal of Biological …, 1994 - ASBMB
Hepatocyte growth factor (HGF) is a potent mitogen for hepatocytes and renal tubular
epithelial cells and may play an important role in regeneration following hepatic and renal
injury. HGF is first synthesized as a single chain precursor which is then converted to a
heterodimeric form by proteolytic processing. This proteolytic conversion is required for HGF
to function as a mitogen. In this study, we examined whether the proteolytic activation of HGF
occurred in response to hepatic and renal injury. HGF remained as an inactive single chain …
epithelial cells and may play an important role in regeneration following hepatic and renal
injury. HGF is first synthesized as a single chain precursor which is then converted to a
heterodimeric form by proteolytic processing. This proteolytic conversion is required for HGF
to function as a mitogen. In this study, we examined whether the proteolytic activation of HGF
occurred in response to hepatic and renal injury. HGF remained as an inactive single chain …
