Allograft arteriopathy: pathogenesis update

RN Mitchell - Cardiovascular pathology, 2004 - Elsevier
Allograft arteriopathy is a vascular intimal proliferative process that occurs in all solid organ
transplants and stands as the single most significant obstacle to successful long-term solid
organ transplantation; it shares a number of pathologic features with restenosis lesions and
atherosclerosis. This article will review some of the newer developments in our
understanding of the immunological and vascular biology underpinnings of the disease,
including the roles played by cytokine and chemokine mediators in recruiting and activating …