Effects of pituitary adenylate cyclase-activating polypeptide on the cyclooxygenase pathway of rat platelets and on platelet: Aggregation☆
B Kis, Z Mezei, G Dancsó, J Pataricza, Á Gecse… - Prostaglandins & other …, 1999 - Elsevier
Several data suggest that pituitary adenylate cyclase-activating polypeptide (PACAP) is
involved in the regulation of local circulation. One possible role of PACAP in the regulation
of circulation is that, it may modify the cyclooxygenase pathway of the arachidonate cascade
in platelets. Our study was designed to study the effect of PACAP on the cyclooxygenase
pathway of rat platelets and on platelet aggregation. PACAP (10− 7 and 10− 6 M)
significantly inhibited the cyclooxygenase pathway of platelets, mostly the thromboxane …
involved in the regulation of local circulation. One possible role of PACAP in the regulation
of circulation is that, it may modify the cyclooxygenase pathway of the arachidonate cascade
in platelets. Our study was designed to study the effect of PACAP on the cyclooxygenase
pathway of rat platelets and on platelet aggregation. PACAP (10− 7 and 10− 6 M)
significantly inhibited the cyclooxygenase pathway of platelets, mostly the thromboxane …
