Costimulation of Gi-and G12/G13-mediated signaling pathways induces integrin αIIbβ3 activation in platelets
B Nieswandt, V Schulte, A Zywietz, MP Gratacap… - Journal of Biological …, 2002 - ASBMB
Platelet activation is a complex process induced by a variety of stimuli, which act in concert
to ensure the rapid formation of a platelet plug at places of vascular injury. We show here
that fibrillar collagen, which initiates platelet activation at the damaged vessel wall, activates
only a small fraction of platelets in suspension directly, whereas the majority of platelets
becomes activated by mediators released from collagen-activated platelets. In Gα q-deficient
platelets that do not respond with activation of integrin α IIb β 3 to a variety of mediators like …
to ensure the rapid formation of a platelet plug at places of vascular injury. We show here
that fibrillar collagen, which initiates platelet activation at the damaged vessel wall, activates
only a small fraction of platelets in suspension directly, whereas the majority of platelets
becomes activated by mediators released from collagen-activated platelets. In Gα q-deficient
platelets that do not respond with activation of integrin α IIb β 3 to a variety of mediators like …
