[HTML][HTML] Coordinated signaling through both G12/13 and Gi pathways is sufficient to activate GPIIb/IIIa in human platelets
RT Dorsam, S Kim, J Jin, SP Kunapuli - Journal of Biological Chemistry, 2002 - ASBMB
Activation of GPIIb/IIIa is known to require agonist-induced inside-out signaling through G q,
G i, and G z. Although activated by several platelet agonists, including thrombin and
thromboxane A 2, the contribution of the G 12/13 signaling pathway to GPIIb/IIIa activation
has not been investigated. In this study, we used selective stimulation of G protein pathways
to investigate the contribution of G 12/13 activation to platelet fibrinogen receptor activation.
YFLLRNP is a PAR-1-specific partial agonist that, at low concentrations (60 μm), selectively …
G i, and G z. Although activated by several platelet agonists, including thrombin and
thromboxane A 2, the contribution of the G 12/13 signaling pathway to GPIIb/IIIa activation
has not been investigated. In this study, we used selective stimulation of G protein pathways
to investigate the contribution of G 12/13 activation to platelet fibrinogen receptor activation.
YFLLRNP is a PAR-1-specific partial agonist that, at low concentrations (60 μm), selectively …