Promoter structure and cell cycle dependent expression of the human methylpurine-DNA glycosylase gene
M Bouziane, F Miao, SE Bates, L Somsouk… - Mutation Research/DNA …, 2000 - Elsevier
The methylpurine-DNA glycosylase (MPG) gene coding for human 3-methyladenine (3-
meAde)-DNA glycosylase functions in the first step of base excision repair (BER) to remove
numerous damaged bases including 3-meGua, ethenoadenine, and hypoxanthine (Hx) in
addition to 3-meAde. In this report, we identify the length of the minimal MPG promoter
region, demonstrate the involvement of several transcription factors in expression of the
MPG gene, and determine the point at which transcription initiates. We also demonstrate that …
meAde)-DNA glycosylase functions in the first step of base excision repair (BER) to remove
numerous damaged bases including 3-meGua, ethenoadenine, and hypoxanthine (Hx) in
addition to 3-meAde. In this report, we identify the length of the minimal MPG promoter
region, demonstrate the involvement of several transcription factors in expression of the
MPG gene, and determine the point at which transcription initiates. We also demonstrate that …
