Etheno DNA-base adducts from endogenous reactive species
J Nair, A Barbin, I Velic, H Bartsch - Mutation Research/Fundamental and …, 1999 - Elsevier
Promutagenic etheno (ε) adducts in DNA are generated through reactions of DNA bases
with LPO products derived from endogenous sources or from exposure to several
xenobiotics. The availability of sensitive methods has made it possible to detect three ε-
adducts in vivo, namely εdA, εdC and N2, 3-εdG. One probable endogenous source for the
formation of these adducts arises from LPO products such as trans-4-hydroxy-2-nonenal
(HNE), resulting in highly variable background ε-adduct levels in tissues from unexposed …
with LPO products derived from endogenous sources or from exposure to several
xenobiotics. The availability of sensitive methods has made it possible to detect three ε-
adducts in vivo, namely εdA, εdC and N2, 3-εdG. One probable endogenous source for the
formation of these adducts arises from LPO products such as trans-4-hydroxy-2-nonenal
(HNE), resulting in highly variable background ε-adduct levels in tissues from unexposed …