Infection by bacteria, parasites or viruses and tissue inflammation such as gastritis, hepatitis
and colitis are recognized risk factors for human cancers at various sites. Nitric oxide (NO)
and other oxygen radicals produced in infected and inflamed tissues could contribute to the
process of carcinogenesis by different mechanisms, which are discussed on the basis of
authors' studies on liver fluke infection and cholangiocarcinoma development. A similar
mechanism could apply to other suspected and known cancer-causing agents including …