Mechanisms of suppression of experimental autoimmune encephalomyelitis by intravenous administration of myelin basic protein: role of regulatory spleen cells
Experimental allergic encephalomyelitis (EAE) can be downregulated by intravenous (iv)
administration of myelin basic protein (MBP). In this report we show that downregulation of
EAE by two 500-μg doses of MBP administered iv before immunization was associated with
reduced encephalitogenicity of both spleen and lymph node cells (day 12 postimmunization)
in adoptive transfer studies. However, efficient downregulation of EAE by two 500-μg iv
doses of MBP on days 10 and 11 after active immunization (at the time of disease onset) …
administration of myelin basic protein (MBP). In this report we show that downregulation of
EAE by two 500-μg doses of MBP administered iv before immunization was associated with
reduced encephalitogenicity of both spleen and lymph node cells (day 12 postimmunization)
in adoptive transfer studies. However, efficient downregulation of EAE by two 500-μg iv
doses of MBP on days 10 and 11 after active immunization (at the time of disease onset) …
