Assessment of eosinophil and neutrophil participation in atopic dermatitis: comparison with the IgE-mediated late-phase reaction
NL Ott, GJ Gleich, EA Peterson, T Fujisawa… - Journal of allergy and …, 1994 - Elsevier
We hypothesized that repeated IgE-mediated late-phase reactions are critical in the
pathogenesis of atopic dermatitis (AD). Prior studies have shown that extracellular
deposition of eosinophil granule major basic protein (MBP) occurs in lesional AD skin,
despite a paucity of infiltrating eosinophils, and that deposition of both neutrophil and
eosinophil granule proteins occurs in the IgE-mediated late-phase reaction. We evaluated
the participation of both eosinophil and neutrophil granule proteins in AD. Cutaneous biopsy …
pathogenesis of atopic dermatitis (AD). Prior studies have shown that extracellular
deposition of eosinophil granule major basic protein (MBP) occurs in lesional AD skin,
despite a paucity of infiltrating eosinophils, and that deposition of both neutrophil and
eosinophil granule proteins occurs in the IgE-mediated late-phase reaction. We evaluated
the participation of both eosinophil and neutrophil granule proteins in AD. Cutaneous biopsy …
