ski can cause selective growth of skeletal muscle in transgenic mice.
P Sutrave, AM Kelly, SH Hughes - Genes & development, 1990 - genesdev.cshlp.org
P Sutrave, AM Kelly, SH Hughes
Genes & development, 1990•genesdev.cshlp.orgWe have created several lines of mice that contain a truncated chicken c-ski cDNA linked to
an MSV LTR promoter. Adult mice from three independent lines show large increases in
skeletal muscle. All three lines of mice express high levels of c-ski mRNA and protein in
skeletal muscle. All other tissues examined show little or no expression of the c-ski
transgene. The muscles of one of the three lines were examined in more detail. Type II fast
fibers undergo selective hypertrophy in affected muscles of this line.
an MSV LTR promoter. Adult mice from three independent lines show large increases in
skeletal muscle. All three lines of mice express high levels of c-ski mRNA and protein in
skeletal muscle. All other tissues examined show little or no expression of the c-ski
transgene. The muscles of one of the three lines were examined in more detail. Type II fast
fibers undergo selective hypertrophy in affected muscles of this line.
We have created several lines of mice that contain a truncated chicken c-ski cDNA linked to an MSV LTR promoter. Adult mice from three independent lines show large increases in skeletal muscle. All three lines of mice express high levels of c-ski mRNA and protein in skeletal muscle. All other tissues examined show little or no expression of the c-ski transgene. The muscles of one of the three lines were examined in more detail. Type II fast fibers undergo selective hypertrophy in affected muscles of this line.
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