[HTML][HTML] Constitutive release of ATP and evidence for major contribution of ecto-nucleotide pyrophosphatase and nucleoside diphosphokinase to extracellular …
ER Lazarowski, RC Boucher, TK Harden - Journal of Biological Chemistry, 2000 - ASBMB
Nucleotides are important extracellular signaling molecules. At least five mammalian P2Y
receptors exist that are specifically activated by ATP, UTP, ADP, or UDP. Although the
existence of ectoenzymes that metabolize extracellular nucleotides is well established, the
relative flux of ATP and UTP through their extracellular metabolic products remains
undefined. Therefore, we have studied the kinetics of accumulation and metabolism of
endogenous ATP in the extracellular medium of four different cell lines. ATP concentrations …
receptors exist that are specifically activated by ATP, UTP, ADP, or UDP. Although the
existence of ectoenzymes that metabolize extracellular nucleotides is well established, the
relative flux of ATP and UTP through their extracellular metabolic products remains
undefined. Therefore, we have studied the kinetics of accumulation and metabolism of
endogenous ATP in the extracellular medium of four different cell lines. ATP concentrations …
