A single dominant susceptible gene determines spontaneous development of thymoma in BUF/Mna rat
M MATSUYAMA, C YAMADA, H HIAI - Japanese Journal of Cancer …, 1986 - jstage.jst.go.jp
M MATSUYAMA, C YAMADA, H HIAI
Japanese Journal of Cancer Research GANN, 1986•jstage.jst.go.jpRats of the BUF/Mna strain developed spontaneous epithelial thymomas morphologically
indistinguishable from human homologues at virtually 100% incidence. Segregation of
thymoma development among crosses between BUF/Mna and ACI/NMs, which has 0%
thymoma incidence, indicated that thymoma susceptibility was determined principally by a
single autosomal dominant gene Tbm-1 (thymoma in BUF/Mna rats). In these crosses,
another autosomal dominant or semidominant gene (s) contributed by ACI/NMs parents …
indistinguishable from human homologues at virtually 100% incidence. Segregation of
thymoma development among crosses between BUF/Mna and ACI/NMs, which has 0%
thymoma incidence, indicated that thymoma susceptibility was determined principally by a
single autosomal dominant gene Tbm-1 (thymoma in BUF/Mna rats). In these crosses,
another autosomal dominant or semidominant gene (s) contributed by ACI/NMs parents …
Rats of the BUF/Mna strain developed spontaneous epithelial thymomas morphologically indistinguishable from human homologues at virtually 100% incidence. Segregation of thymoma development among crosses between BUF/Mna and ACI/NMs, which has 0% thymoma incidence, indicated that thymoma susceptibility was determined principally by a single autosomal dominant gene Tbm-1 (thymoma in BUF/Mna rats). In these crosses, another autosomal dominant or semidominant gene (s) contributed by ACI/NMs parents moderately reduced the thymorna incidence.
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