The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme
J Yuan, S Shaham, S Ledoux, HM Ellis, HR Horvitz - Cell, 1993 - cell.com
J Yuan, S Shaham, S Ledoux, HM Ellis, HR Horvitz
Cell, 1993•cell.comWe have cloned the C. elegans cell death gene ted-3. A ted-3 transcript is most abundant
during embryogenesis, the stage during which most programmed cell deaths occur. The
predicted CED3 protein shows similarity to human and murine interleukin-1 P-converting
enzyme and to the product of the mouse nedd-2 gene, which is expressed in the embryonic
brain. The sequences of 12 ted-3 mutations as well as the sequences of ted-3 genes from
two related nematode species identify sites of potential functional importance. We propose …
during embryogenesis, the stage during which most programmed cell deaths occur. The
predicted CED3 protein shows similarity to human and murine interleukin-1 P-converting
enzyme and to the product of the mouse nedd-2 gene, which is expressed in the embryonic
brain. The sequences of 12 ted-3 mutations as well as the sequences of ted-3 genes from
two related nematode species identify sites of potential functional importance. We propose …
Summary
We have cloned the C. elegans cell death gene ted-3. A ted-3 transcript is most abundant during embryogenesis, the stage during which most programmed cell deaths occur. The predicted CED3 protein shows similarity to human and murine interleukin-1 P-converting enzyme and to the product of the mouse nedd-2 gene, which is expressed in the embryonic brain. The sequences of 12 ted-3 mutations as well as the sequences of ted-3 genes from two related nematode species identify sites of potential functional importance. We propose that the CED-3 protein acts as a cysteine protease in the initiation of programmed cell death in C. elegans and that cysteine proteases also function in programmed cell death in mammals.
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