Tumor suppressor MMAC/PTEN inhibits cytokine-induced NFκB activation without interfering with the IκB degradation pathway
D Koul, Y Yao, JL Abbruzzese, WKA Yung… - Journal of Biological …, 2001 - ASBMB
The phosphoinositide 3-kinase (PI 3-kinase) pathway has been implicated in the activation
of the proinflammatory transcription factor nuclear factor κB (NFκB). To investigate the role of
this pathway in NFκB activation, we employed mutated in multiple advanced
cancers/phosphatase and tensin homologue (MMAC/PTEN), a natural antagonist of PI 3-
kinase activity. Our results show that cytokine-induced DNA binding and transcriptional
activities of NFκB were both inhibited in a glioma cell line that was stably transfected with …
of the proinflammatory transcription factor nuclear factor κB (NFκB). To investigate the role of
this pathway in NFκB activation, we employed mutated in multiple advanced
cancers/phosphatase and tensin homologue (MMAC/PTEN), a natural antagonist of PI 3-
kinase activity. Our results show that cytokine-induced DNA binding and transcriptional
activities of NFκB were both inhibited in a glioma cell line that was stably transfected with …
