Sulphasalazine is a potent inhibitor of prostaglandin 15‐hydroxydehydrogenase: possible basis for therapeutic action in ulcerative colitis
JRS Hoult, PK Moore - British Journal of Pharmacology, 1978 - Wiley Online Library
JRS Hoult, PK Moore
British Journal of Pharmacology, 1978•Wiley Online LibrarySulphasalazine is a potent and selective inhibitor in vitro of prostaglandin 15‐
hydroxydehydrogenase in rabbit colon (ID5 ()= 50 μm) and in several other organs of
different species, but does not inhibit prostaglandin A‐13 reductase or microsomal
prostaglandin synthesis from arachidonic acid. It is suggested that this action may underly
the therapeutic usefulness of sulphasalazine in ulcerative colitis for the prevention of
relapse.
hydroxydehydrogenase in rabbit colon (ID5 ()= 50 μm) and in several other organs of
different species, but does not inhibit prostaglandin A‐13 reductase or microsomal
prostaglandin synthesis from arachidonic acid. It is suggested that this action may underly
the therapeutic usefulness of sulphasalazine in ulcerative colitis for the prevention of
relapse.
Sulphasalazine is a potent and selective inhibitor in vitro of prostaglandin 15‐hydroxydehydrogenase in rabbit colon (ID5() = 50 μm) and in several other organs of different species, but does not inhibit prostaglandin A‐13 reductase or microsomal prostaglandin synthesis from arachidonic acid. It is suggested that this action may underly the therapeutic usefulness of sulphasalazine in ulcerative colitis for the prevention of relapse.
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