A serum-and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein.
MK O'Banion, HB Sadowski, V Winn… - Journal of Biological …, 1991 - ASBMB
The profound influence of glucocorticoid hormones on the inflammatory response includes a
rapid and significant reduction in the synthesis of cyclooxygenase (prostaglandin G/H
synthase, PGHS), the key enzyme for prostaglandin biosynthesis. In analyzing the
glucocorticoid effects on PGHS synthesis in C127 mouse fibroblasts, we detected a novel 4-
kilobase (kb) mRNA that is related to a PGHS cDNA cloned from an ovine seminal vesicle
library. This RNA is much more prevalent in cycloheximide-treated cells and, based on …
rapid and significant reduction in the synthesis of cyclooxygenase (prostaglandin G/H
synthase, PGHS), the key enzyme for prostaglandin biosynthesis. In analyzing the
glucocorticoid effects on PGHS synthesis in C127 mouse fibroblasts, we detected a novel 4-
kilobase (kb) mRNA that is related to a PGHS cDNA cloned from an ovine seminal vesicle
library. This RNA is much more prevalent in cycloheximide-treated cells and, based on …
