Intracellular oxidation/reduction status in the regulation of transcription factors NF-κB and AP-1
D Gius, A Botero, S Shah, HA Curry - Toxicology letters, 1999 - Elsevier
The eukaryotic cell contains a multitude of pathways coupling environmental stimuli to the
specific regulation of gene expression. Two early response transcriptional complexes, NF-
κB and AP-1, appear to respond to environmental stressors by inducing the expression of
response specific downstream genes. Both are well-characterized transcriptional regulatory
factors that are induced by a wide variety of seemingly unrelated exogenous and
endogenous agents and serve important roles in cell growth and differentiation, immunity …
specific regulation of gene expression. Two early response transcriptional complexes, NF-
κB and AP-1, appear to respond to environmental stressors by inducing the expression of
response specific downstream genes. Both are well-characterized transcriptional regulatory
factors that are induced by a wide variety of seemingly unrelated exogenous and
endogenous agents and serve important roles in cell growth and differentiation, immunity …
